GERMAN EPISODE Antibiotika wurden einst als Heilbringer der Menschheit gefeiert und haben dazu beigetragen die durchschnittliche Lebenserwartung stark zu erhöhen. Doch schon in den frühen Tagen warnte der Finder des Penicillins, Sir Alexander Fleming, vor dem unbedachten und verschwenderischen Umgang mit diesen Wundermedikamenten. In dieser Folge beleuchten Andreas Horchler und Louise von Stechow die weltweite Gesundheitskrise, die von antibiotikaresistenten Bakterien hervorgerufen wird und besprechen ihre Ursachen und potentielle Gegenmaßnahmen.

Content and Editing: Louise von Stechow and Andreas Horchler

Disclaimer: Louise von Stechow, Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics, but do not claim to give medical, investment or even life advice in the podcast.

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References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378521/ (antibiotic resistance overview)
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354621/ (antibiotic resistance overview, altered life expectancy)
3. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext (antibiotic resistance overview, Lancet study)
4. https://www.bbc.com/news/health-60058120 (antibiotic resistance overview, Lancet study overview)
5. https://www.who.int/data/stories/the-true-death-toll-of-covid-19-estimating-global-excess-mortality (COVID death statistics WHO)
6. https://www.cdc.gov/media/releases/2015/p0225-clostridium-difficile.html (C diff)
7. https://www.cell.com/trends/genetics/fulltext/S0168-9525(20)30206-7 (Horizontal gene transfer)
8. https://wellcome.org/news/why-is-it-so-hard-develop-new-antibiotics (the difficulties in developing novel antibiotics
9. https://www.nature.com/articles/d41586-020-02884-3 (Nature, why big pharma abandoned antibiotics)
10. https://www.nature.com/articles/d41586-018-02475-3 (Nature - 4 stories of antibiotic breakthroughs)
11. https://www.umu.se/en/news/-new-group-of-antibacterial-molecules-identified_11112855/ (new antibiotics, Karolinska and Uni Bonn)
12. https://pubmed.ncbi.nlm.nih.gov/26089440/#:~:text=Teixobactin%20is%20a%20recently%20described,(provisionally%20named%20Eleftheria%20terrae). (new antibiotics, Teixobactin)
13. https://www.nature.com/articles/s41586-021-03899-0 (new antibiotics, rational design)
14. https://news.mit.edu/2020/artificial-intelligence-identifies-new-antibiotic-0220#:~:text=Using%20a%20machine%2Dlearning%20algorithm,resistant%20to%20all%20known%20antibiotics. (new antibiotics, MIT AI)