GERMAN EPISODE Sogenannte Gene Drives sind spezielle Genveränderungsmethoden, die es Wissenschaftlern zum ersten Mal erlauben die Grenzen der klassischen Evolution nach Darwin zu sprengen und ihr Grundprinzip, die natürliche Selektion zu überwinden, in dem sie die Expression in allen Nachkommen erzwingen. In dieser Episode unterhalten sich Andreas Horchler und Louise von Stechow darüber wie Gene Drives in der Malariaprävention, in der Bewahrung bedrohter Arten und zur Erhöhung von Ernteerträgen eingesetzt werden könnten – und wie gefährlich diese Technologie in der Hand eines einzelnen Wissenschaftlers sein kann.

Content and Editing: Louise von Stechow and Andreas Horchler

Disclaimer: Louise von Stechow, Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics, but do not claim to give medical, investment or even life advice in the podcast.

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References 1) https://www.nature.com/articles/d41586-019-02087-5 2) https://pubmed.ncbi.nlm.nih.gov/21508956/ 3) https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021 4) https://www.statnews.com/2017/03/14/malaria-mosquitoes-burkina-faso/ 5) https://www.statnews.com/2016/12/14/gene-drive-students-igem/ 6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675690/ 7) https://www.statnews.com/2015/12/07/gene-edited-mosquitoes-stop-malaria/ 8) https://psmag.com/ideas/most-controversial-tree-in-the-world-gmo-genetic-engineering 9) https://theconversation.com/genetically-modified-mosquitoes-could-be-released-in-florida-and-texas-beginning-this-summer-silver-bullet-or-jumping-the-gun-139710 10) https://www.editingnature.org/ 11) https://www.statnews.com/2015/11/12/gene-drive-bioterror-risk/#:~:text=The%20possibilities%20for%20%E2%80%9Cweaponizing%E2%80%9D%20gene,who%20briefed%20the%20bioweapons%20office. 12) https://www.ajtmh.org/view/journals/tpmd/96/3/article-p530.xml 13) https://elifesciences.org/articles/03401 14) https://www.pnas.org/doi/10.1073/pnas.1805874115 15) https://www.etcgroup.org/content/reckless-driving-gene-drives-and-end-nature 16) https://www.vice.com/en/article/kz49ge/this-gene-technology-could-change-the-world-its-maker-isnt-sure-it-should-v26n4 17) https://medium.com/mit-media-lab/daisy-drives-will-let-communities-alter-wild-organisms-in-local-ecosystems-cb626c5a9f38#.91i6eyhc0